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Omega-3 Fatty Acids: EPA, DHA, Quality, and Intake

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Omega-3 Fatty Acids: EPA, DHA, Quality, and Intake

Omega-3 is not a single fatty acid, but a group of polyunsaturated fatty acids. For nutrition, ALA, EPA and DHA are particularly relevant. ALA is found predominantly in plant-based foods. EPA and DHA are found mainly in fish, seafood and algal oil.

For the targeted intake of long-chain omega-3 fatty acids, one question is particularly important: How many milligrams of EPA and DHA are actually consumed?

The human body can convert ALA into EPA and DHA, but only to a limited extent. Therefore, ALA, EPA and DHA should not simply be treated as equivalent under the umbrella term omega-3.

EPA AND DHA ARE WHAT MATTER

When it comes to omega-3 supplements, you will encounter many figures: 1,000 mg of fish oil, 2,000 mg of fish oil per daily serving, or a particularly high total omega-3 content.

For targeted EPA/DHA intake, however, the amount of fish oil is not the decisive reference value. What matters is:

EPA per capsule. DHA per capsule. EPA + DHA per capsule.

Two capsules can each contain 1,000 mg of fish oil and still provide completely different amounts of EPA and DHA. Figures stated per daily serving can also make comparisons more difficult because, depending on the manufacturer, these may refer to one, two, three or more capsules.

EPA and DHA are also at the centre of a large proportion of human research. They are incorporated into cell membranes, influence lipid metabolism and serve as precursors for various lipid mediators. DHA is also found in high concentrations in the brain and retina.

QUALITY REQUIRES MEASURED VALUES

The amount of active ingredients, however, is only the first part of assessing quality. What an omega-3 supplement contains in addition is equally relevant.

For marine oils, analyses for relevant contaminants such as heavy metals, dioxins and PCBs are therefore part of a sound quality control process.

There is an important distinction between “below the legal maximum level” and “below the detection limit”. In the first case, a substance may be measurably present but remains within legal limits. In the second case, the method used did not detect a concentration above its detection limit.

This is why statements such as “laboratory tested”, a quality seal or a certificate of marketability are not sufficient for a detailed quality assessment. What matters are specific measured values.

A complete laboratory report, preferably specific to the batch, should show what was tested, which values were measured and which detection limits were used.

FRESHNESS CAN BE MEASURED

With fish oil, there is another dimension of quality: the oxidation of the fish oil, i.e. how fresh was it after filling? EPA and DHA contain multiple double bonds and are therefore comparatively susceptible to oxidation. Oxygen, light, temperature and storage time can influence oxidation.

One important parameter is the TOTOX value. For consumers, the principle is more important than the calculation: The lower the measured oxidation, the less oxidised the oil was at the time of analysis.

The GOED specification sets a maximum TOTOX value of 26 as a quality limit. A value well below 10 indicates very low measured oxidation. However, there is no universally defined threshold for the term “very fresh”.

It is also important when the measurement was taken. An excellent TOTOX value for the raw oil does not automatically describe the condition of the capsules subsequently sold. Processing, transport, encapsulation and storage all take place in between.

Therefore, a current TOTOX value for the actual batch of the finished product being sold is considerably more informative than a general value for the original raw oil.

THE OMEGA-3 INDEX

Even knowing the exact EPA/DHA dose does not tell us what status a person actually achieves. The Omega-3 Index describes the proportion of EPA and DHA among the fatty acids in red blood cell membranes. It was proposed in 2004 by William S. Harris and Clemens von Schacky and enables a longer-term assessment of EPA/DHA status.

This makes it possible to approach an omega-3 routine based on data:

Measure. Assess. Adjust diet or supplementation if necessary. Measure again.

Observational studies show interesting associations between a higher Omega-3 Index and a lower risk of mortality. In an analysis of older participants in the Framingham Heart Study, the statistical difference between a low and high Omega-3 Index corresponded to approximately 4.74 years of life in the model. However, this does not prove that increasing the Omega-3 Index extends life by this amount of time. It is an association, not a randomised intervention.

→ Read more: The Omega-3 Index

RISKS IN CONTEXT

Potential risks of omega-3 also require context. In the case of atrial fibrillation, studies show a relative increase in risk of approximately 20 to 25 percent. In absolute terms, however, the risk increased only from approximately 3.3 to 4.0 percent over several years, corresponding to around 7 additional cases per 1,000 people.

The baseline situation is also crucial. In healthy people, the absolute change remains small, while in people with pre-existing cardiovascular conditions it may be more relevant. Age, cardiovascular disease and regular alcohol consumption also influence the risk.

Supplementation must therefore always be considered in the individual context. In the case of pre-existing conditions or regular medication use, supplementation should be discussed with a physician.

The relevant question is always: How large is the absolute change in risk for the individual person, and what potential benefit does it need to be weighed against?

→ Read more: Omega-3 and Atrial Fibrillation

WHY WE ANALYSE MORE THAN 83 PARAMETERS

These criteria also define our own quality standards. We do not only want to know which specifications a raw material meets. We want to know what can actually be measured in the finished capsule.

That is why we have VITAQ® Omega-3 1.100 independently tested on a batch-specific basis for more than 83 parameters. These include the actual fatty acid content, oxidation parameters, heavy metals, dioxins, PCBs and microbiological parameters.

We publish the results. Because “laboratory tested” should not be a promise of trust, but should mean verifiable data.

For VITAQ®, we use EPAX fish oil in rTG form. For us, the choice of raw material is one component of product quality, but it is not a substitute for analysing the finished product. The current batch remains decisive.

EFSA HEALTH CLAIMS

250 mg EPA and DHA daily: “EPA and DHA contribute to the normal function of the heart.” (Permitted claim with a daily intake of 250 mg EPA and DHA.)

250 mg DHA daily: “DHA contributes to the maintenance of normal brain function. DHA contributes to the maintenance of normal vision.” (This claim may be used with a daily intake of 250 mg DHA.)

2,000 mg EPA and DHA daily: “EPA and DHA contribute to the maintenance of normal blood pressure.” (Permitted with a daily intake of 2,000 mg EPA and DHA.)

3,000 mg EPA and DHA daily: “EPA and DHA contribute to the maintenance of normal blood triglyceride levels.” (Permitted with a daily intake of 3,000 mg EPA and DHA.)

Source: EFSA Journal 2009;7(9):1263