Griffonia Simplicifolia (5-HTP)
History and use in traditional medicine
Griffonia simplicifolia is a plant native to West Africa, mainly found in countries such as Ghana, Côte d'Ivoire and Togo. It thrives in tropical rainforests and has been used in traditional African medicine for centuries. In the past, Griffonia simplicifolia seeds were prized for their medicinal properties, particularly their mood-enhancing effects and their ability to treat various ailments. Traditional healers often used the plant to treat wounds, digestive problems and psychological problems. In the mid-20th century, Griffonia simplicifolia gained international attention, particularly in Europe, where it became known for its high 5-hydroxytryptophan (5-HTP) content. This compound was used as a natural remedy for depression, anxiety and sleep disorders before the advent of modern antidepressants. Despite its long history in traditional medicine, global interest in Griffonia simplicifolia and its potential health benefits continues to grow, primarily due to its role as a natural source of 5-HTP.
What is Griffonia simplicifolia?
Griffonia simplicifolia is a tropical shrub from the legume family. It is best known for its seeds, which contain a high concentration of 5-hydroxytryptophan (5-HTP), a natural amino acid that serves as a precursor to the neurotransmitter serotonin. Serotonin plays a crucial role in regulating mood, sleep and appetite, making 5-HTP an important compound for mental and emotional well-being. Griffonia simplicifolia seeds are often harvested and processed into dietary supplements marketed for their mood-boosting, sleep-inducing and weight-regulating effects. Although Griffonia simplicifolia is mainly known for its 5-HTP content, the plant may also contain other bioactive compounds that contribute to its health benefits. However, further research is needed to understand the full spectrum of compounds contained in Griffonia simplicifolia and their effects on human health. The natural habitat and traditional use of the shrub underline its importance as a valuable botanical resource.
Use of 5-HTP in modern medicine
In Europe, 5-HTP extracted from Griffonia simplicifolia was used in medicine in the mid-20th century. It was widely used to treat depression, anxiety and sleep disorders, as it was recognized that 5-HTP could increase serotonin production in the brain. This compound offered a natural alternative to the limited pharmacological options available at the time. However, with the introduction of selective serotonin reuptake inhibitors (SSRIs) in the 1980s, 5-HTP faded into the background.
Ingredients of Griffonia simplicifolia
The most important compound in Griffonia simplicifolia is 5-hydroxytryptophan (5-HTP), an amino acid that serves as a direct precursor of serotonin. Griffonia simplicifolia seeds contain up to 20 % 5-HTP, making them one of the richest natural sources of this compound. Serotonin plays a crucial role in various bodily functions, including the regulation of mood, the sleep cycle and appetite control.
In addition, 5-HTP can cross the blood-brain barrier without the need for an active carrier, allowing it to effectively increase serotonin levels in the brain. In addition to 5-HTP, Griffonia simplicifolia may contain other bioactive compounds, but these have not yet been studied as extensively. The seeds of the plant are particularly valued for their high 5-HTP content, which has made them a focus of research in the natural treatment of mood disorders, anxiety and sleep disorders.
5-HTP & Longevity
Griffonia simplicifolia has the potential to support healthy ageing and longevity through its active ingredient 5-HTP, particularly by promoting improved mood and mental well-being. As we age, maintaining a positive mood and stable mental health becomes increasingly important for overall quality of life. By increasing serotonin levels in the brain, 5-HTP from Griffonia simplicifolia could promote emotional balance, reduce anxiety and improve sleep quality - all factors that may contribute to a sense of well-being. Although more research is needed to fully understand the long-term benefits, taking 5-HTP supplements from Griffonia simplicifolia could play a role in improving mood and mental health as part of a holistic approach to healthy ageing. However, a doctor should be consulted before taking any new supplement, especially as serotonin levels and mood regulation are complex processes that are influenced by many factors.
Caution when combining with neuroleptics
5-HTP should not be taken with a neuroleptic prescribed as an antidepressant or for other cognitive purposes unless approved by your doctor. The reason for this is possible interactions with other medications and the theoretical risk of serotonin syndrome (a life-threatening condition that could be caused by excessive serotonin levels in the body).
Griffonia extract with DNA certificate
Our experts have once again outdone themselves with this raw material. Since many extracts are subsequently chemically enriched or plants are mixed, we have opted for an exclusive raw material from Europe, where the raw material used for this extract has been DNA-certified to ensure the authenticity and traceability of the plant source. Griffonia simplicifolia extract is produced in the EU from Griffonia simplicifolia seeds actually harvested in the wild and originating from West Africa. It is a water extraction. The end product is standardized and contains 20 % 5-hydroxytryptophan (5-HTP). The quality complies with strict European regulations for contaminants, including pesticides, aflatoxins and microbiological safety. The extract is non-GMO, gluten-free and suitable for vegan diets.
